While I'm looking forward to playing with the family in GW2, it looks like the common curse of Oceanic onling gaming is going to rear it's ugly head here as well. From my own experiences, and a lot of what I read on the net, with our 200-400ms pings, Australian players in particular are going to be disadvantaged in the pvp side of the game.
The dodge mechanic does rely on player skill, but latency does factor in and I found myself getting hit a lot by things I thought I had dodged, and missing a lot of attacks which looked like they had hit to my screen. I'd be interested to know if anyone else noticed this, and maybe had some ideas for proxy or tunneling service that could help.